10 Natural Supplements That May Benefit Sickle Cell Anemia Patients

I have been asked many times to share the list of Vitamins and Herbs we use to keep our Sickle Cell Warrior Dylan healthy.  Dylan is 4 years old and has been taking most of these for close to 2yrs or more.  These are the exact brands we use for his care.  I notice differences when we’ve tried other brands so I’ve stayed loyal to these specific brands.

Liquid Chlorophyll 

Dylan has been taking this brand of Liquid Chlorophyll for over 2 yrs.  In my initial research on natural ways to treat Sickle Cell Anemia this potent plant supplement came up consistently.  I also give it to my younger son and it helps with his stubborn bowels.  This is where we started our natural journey and I believe it has truly been integral in keeping Dylan crisis free for over 2 years.

“On a molecular level, the structure of chlorophyll is very similar to heme, which is a part of hemoglobin present in human blood. Heme, which is what makes blood appear bright red once exposed to oxygen, is bound to proteins forming hemoglobin. Hemoglobin carries oxygen to the lungs and other respiratory surfaces to be released into tissues throughout the body.” (1 )



The Hematologist prescribed Folic Acid for Dylan immediately.  After discovering the dangers of Folic Acid, which is the synthetic form of Folate we switched to this brand of Folate which Dylan takes daily.  I wrote a full article on Folic Acid here if you’d like to read more.  Folic Acid Facts

Vitamin D3

Vitamin D deficiency is running rampant in all populations, but is extremely high in Sickle Cell patients. I’ve read numerous articles that suggest 98% of the Sickle Cell population having a Vitamin D deficiency. The research for the Vitamin D3 as it specifically impacts Sickle Cell patients is ongoing.  There are currently studies in process to assess the benefits of high doses of D3 up to 7000 IU daily for SCD patients.

“Research in school aged children shows that taking a vitamin D supplement during winter might reduce the chance of developing seasonal flu……..Some additional research suggests that children with low levels of vitamin D have a higher chance of developing a respiratory infection such as the common cold or flu. ” (2 )

Dylan has been diagnosed with the Flu, RSV and Pneumonia.  All of these were lengthy hospital stays.  Since we started him on a high dosage of Vitamin D3 (5,000 IU) he has not had any severe respiratory symptoms. He had one short hospital stay which was less than 48hrs due to fever, but because his numbers were so good they sent him home.

Vitamin E

Vitamin is new to our regimen. Dylan has been taking it for less than a year.Here are my thoughts as a non medical professional.  Sickle Cell is a silent disease at times and you can forget what could be possibly occurring in the body.   When I’m evaluating supplements I always consider that red blood cells have the potential to be sickling and not causing pain, but causing silent damage to organs.  When I see improved blood circulation or “anti inflammatory” I always investigate those herbs or supplements further.

“Vitamin E is an antioxidant and eliminates fatigue by promoting blood circulation and can also strengthen your capillary walls and nourish your cells.” (3)


Zinc is well know for its immune boosting properties.  Its included in almost every natural cold remedy and cough drop sold on the market.  What I didn’t know was “Zinc can help with a liver cleanse to reduce inflammation in the liver, reduces free radical damage, helps with nutrient absorption and allows for proper waste elimination” (4)

Sickle cell patients typically have jaundice (yellow eyes) because their liver is processing dead red blood cells.  Sickled cells typically die 10-20 days where normal red blood cells live on average 120 days.  The liver eliminates waste from the blood and when there is a back up of waster jaundice can occur.

B 12

“Vitamin B12 deficiency anemia is a condition in which your body does not have enough healthy red blood cells, due to a lack (deficiency) of vitamin B12. This vitamin is needed to make red blood cells, which carry oxygen to all parts of your body. Without enough red blood cells, your tissues and organs don’t get enough oxygen. Without enough oxygen, your body can’t work as well.” (5)

This describes every Sickle Cell patient.  More and more doctors are adding a full suite of B vitamins as standard treatment for Sickle Cell patients including B6 and B12.

L Glutamine

Endari or L Glutamine was approved by the FDA for treatment of Sickle Cell Disease in patients 5-58 in July of 2017.  I started giving Dylan L Glutamine in October of 2017. We use 1,000mg which is lower than the Endari doses used in the trials. Discuss this prescription with your Hematologist.  L Glutamine is an amino acid.

“Patients who were treated with Endari experienced fewer hospital visits for pain treated with a parenterally administered narcotic or ketorolac (sickle cell crises), on average, compared to patients who received a placebo (median 3 vs. median 4), fewer hospitalizations for sickle cell pain (median 2 vs. median 3), and fewer days in the hospital (median 6.5 days vs. median 11 days).  Patients who received Endari also had fewer occurrences of acute chest syndrome (a life-threatening complication of sickle cell disease) compared with patients who received a placebo” (6 )

L Arginine

“Nitric oxide is a powerful neurotransmitter that helps blood vessels relax and also improves circulation. Some evidence shows that arginine may help improve blood flow in the arteries of the heart. That may improve symptoms of clogged arteries, chest pain or angina, and coronary artery disease.” ( 7)

We have just added this to our regimen and give Dylan 1,000mg daily.

Burdock Root

“If you suffer from an enlarged spleen, burdock root can help. The spleen is a vital “guardian” organ that we rely on to keep the body free from infections, viruses and all kinds of dangerous pathogens. An enlarged spleen is a clear warning sign that the immune system is fighting hard to remove threats from the body but failing to do so because it can’t keep up with high demand.” ( 9)

During our first visit with the Hematologist she taught us how to check to see if Dylan’s spleen was enlarged. Many Sickle Cell patients have their spleen removed because of enlarged non functioning spleens.  I’m grateful that we have not had this issue with Dylan, but I am a firm believer in prevention is better than cure.  We give him 1g of Burdock Root daily.

Yellow Dock

“Traditionally, yellow dock root has been thought to be a blood purifier and general detoxifier, especially for the liver.” (8)

Dylan has been pain free for 2 1/2 yrs but it was not until I added Burdock Root and Yellow Dock did his jaundice improve.

I am not a doctor nor will I ever say that I have all of the answers, but what I do know is that Dylan has not had pain in 2 1/2 years.  His eyes are not yellow and he has not been hospitalized in 7 months. His last hospitalization was for a mild fever and he was released in 36hrs because he was doing so well.  He has never had a blood transfusion and his spleen has never been enlarged.  I know that we are on the right path.  My goal is to keep my warrior healthy and pain free using the most natural methods possible.

Published by Geneva Marie

Geneva is a mom of 3 boys, a college freshman, a 4 and a 5yr old. After her middle son was diagnosed with Sickle Cell anemia she became obsessed with finding natural ways to keep him healthy. Geneva is a Holistic Health and Wellness speaker and Sickle Cell Advocate. She hopes to share more knowledge around the disease to Educators and the community at large. Geneva is also a 2011 NYC marathon finisher and enjoys traveling to destinations with amazing beaches.

Join the Conversation


  1. There is so much I didn’t know about sickle cell anemia. You are an incredible mom for making sure your son has everything he needs to be at his best. I commend you.

    Liked by 1 person

  2. This is a very good post. I once had a patient with sickle cell anemia and it really makes me worried that the parents are not well informed about it. I had to educate his teachers about it.


  3. Thanks so much for all you do, not only for your child, but in sharing the information that will help others too. I have sickle cell trait but I’ve got a friend whose son is a sufferer. Will definitely share.


  4. This post just showed me how little I know about sickle cell anemia. I hope other people with sickle cell are able to find these supplements as useful as they have been with your son so far!


  5. Many good ideas with plenty of research. Very helpful to those seeking information.


  6. Thank you for sharing this post. Very informative! I know I am a Vitamin Deficient. I think it’s always important to take supplements because most of the time we’re not getting it much from food.


  7. That’s pretty amazing. I don’t think we get enough vitamins like this, but we get it through fruits and other stuff.


  8. Blessings to you in your journey! Thank you for sharing your knowledge and experience with others who also need it.


      1. Hi! There is an updated list posted on our IG page. @healthywarriormom. He does take Vitamin C daily. He doesn’t take a probiotic but I use ACV sporadically as a natural probiotic. Seamoss has also been a big addition to our daily regimen along with elderberry syrup.


  9. I love this. My mom used a similar regime to treat my brother’s autism (which is surprising given it is a behavioural condition not a physiological). The power of healthy eating!


  10. For a long time I had a problem with weakness and low iron level. My alternative was on a natural basis (beetroot, red berries, aronia …), a very useful and informative post.


  11. Thanks for sharing this information. I’m an adult living with SSD and this article is very helpful. I’m going pass it on.


  12. Hi, I have a son with enlarged spleen and has SS. I am interested I. Burdock root wanted to know when you started giving Dylan burdock root. I also see you mentioned he has not had any spleen issues?


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